Fig. 1: Hypoxic stress leads to inflammation in lung cancer. | Cell Death & Disease

Fig. 1: Hypoxic stress leads to inflammation in lung cancer.

From: Hypoxic stress suppresses lung tumor-secreted exosomal miR101 to activate macrophages and induce inflammation

Fig. 1

A Gene enrichment analysis on differentially expressed genes between LUSC tumors with low and high expression of HIF1α. B The groups of enriched genes in each pathway. C The heatmap of expression correlation of HIF1α with the genes in the cytokine-cytokine receptor interaction pathway. D The expression correlation of HIF1α and IL1A and IL6 from TCGA database (https://xena.ucsc.edu/welcome-to-ucsc-xena/). E, F The serum levels of IL1A (E) and IL6 (F) in lung cancer patients with low and high HIF1α expression in primary tumors (n = 8 in each group). G Flow cytometry analysis of macrophages in human lung tumors with low and high HIF1α expression. Representative images are shown. H The immunofluorescence staining of CD68 and CA9 in human lung tumors with low and high HIF1α expression. Scale bar, 20 μm. * p < 0.05; ** p < 0.01.

Back to article page