Fig. 3: Alternative splicing is associated with tumor hallmarks.
From: Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment
Five common tumor hallmarks related to alternative splicing include proliferation, invasion and migration, apoptosis, angiogenesis, and drug resistance. The figure shows the hallmarks and the associated genes. A The representative gene and their splicing variants show different functions in cell proliferation. B The representative gene and their splicing variants show different functions in cell apoptosis. C The representative gene and their splicing variants show different functions in angiogenesis. D The representative gene and their splicing variants show different functions in invasion and metastasis. E The representative gene and their splicing variants show different functions in drug resistance. More details about the mechanism of splicing and clinical application are listed in Supplementary Table 1.
