Fig. 7: ALCAP2 attenuates tumour growth in a murine xenograft model. | Cell Death & Disease

Fig. 7: ALCAP2 attenuates tumour growth in a murine xenograft model.

From: ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L

Fig. 7

A A549 cell xenografts in nude mice (n = 6) at the experimental endpoint. ALCAP2 at a concentration of 14 mg/g was injected intraperitoneally every two days, and tumours were harvested and photographed as shown. B Tumour growth curves in mice (n = 6 in each group) inoculated with the indicated cells on the indicated days. C Each tumour was weighed. D β-catenin, NEDD4L cyclin D1, and survivin protein expression in tumours was measured by western blot analysis. E The hypothetical model showing the mechanism by which ALCAP2 plays a role in LUAD cells. ***P < 0.001.

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