Fig. 3: Silencing hsa_circ_0007813 suppressed proliferation, migration, and invasiveness potentials of bladder cancer cells in vivo. | Cell Death & Disease

Fig. 3: Silencing hsa_circ_0007813 suppressed proliferation, migration, and invasiveness potentials of bladder cancer cells in vivo.

From: Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation

Fig. 3

A Luciferase expressing T24 transfected with control shRNA (shCtrl) and shRNA (shCirc) were used to establish subcutaneous xenograft models. In vivo bioluminescence imaging was used to monitor tumor growth (P < 0.05, N = 3, Kruskal–Wallis test). B Ki67 IHC staining of tumor tissues dissected from subcutaneous xenograft models (Scale bars represent 100 μm). C Bioluminescence imaging of mice metastasis models (N = 1). D Representative H&E-stained slices of lungs taken from shCtrl and shCirc bearing mice (Scale bars in the second column represent 500 μm; Scale bars in the first and third columns represent 100 μm). All error bars in the figures indicated the standard deviation of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.

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