Fig. 6: LINC00671/LDHA axis regulates TC tumor growth and lung metastasis in vivo. | Cell Death & Disease

Fig. 6: LINC00671/LDHA axis regulates TC tumor growth and lung metastasis in vivo.

From: STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis

Fig. 6

A, B TPC-1 cells stably infected with the lentivirus carrying the indicated constructs were injected subcutaneously into nude mice (n = 8 per group). The tumor volume was measured every 5 days and the growth curve was plotted (B). C Representative IHC staining of LDHA, Ki67, and H&E images of tumors resected from (A). Scale bar, 50 µm. The scattered plot shows the expression levels of LINC00671 measured by qRT-PCR. D TPC-1 cells stably expressing the constructs were injected through the tail vein to establish a thyroid cancer cell metastasis model in nude mice (n = 8 per group). Anatomical and histological analyses of representative lung metastases were performed. The number of tumor nodules was observed under the anatomical microscope. Symbols represent individual mice. **P < 0.01 versus the corresponding control.

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