Fig. 7: PPFIBP1 may promote MMP-2 expression through activation of JNK and c-Jun.
From: PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway
A Up: the expression of pY397 FAK, normalized to FAK, and the expression of pY416 Src, normalized to Src, and quantification of other indicated proteins normalized to GAPDH. Down: representative images of IHC analysis of indicated proteins in the intracranial tumors formed by U251 MG cells with PP-OE or the vector control. The figures are representative data from at least three independent experiments. B Western blot analysis of indicated proteins in PP-OE and the Ctrl glioma cells. The numbers represent the expression of phosphorylation proteins normalized to total proteins, or quantification of other indicated proteins, normalized to GAPDH. The figures are representative data from at least three independent experiments. C A schematic representation of the proposed pathway by which PPFIBP1 promotes cell migration and tumor invasion in GBM cells. The figures are representative data from at least three independent experiments. *P < 0.05, **P < 0.01.
