Fig. 6: ZFAS1 exerts its oncogenic activity through regulating the miR-497-5p/HMGA2 axis in vivo. | Cell Death & Disease

Fig. 6: ZFAS1 exerts its oncogenic activity through regulating the miR-497-5p/HMGA2 axis in vivo.

From: Long non-coding RNA ZFAS1 promotes pancreatic cancer proliferation and metastasis by sponging miR-497-5p to regulate HMGA2 expression

Fig. 6

A The excision tumour in nude mice of PC xenograft model. B Differences in tumour volume among groups. C PCR identified ZFAS1 and miR-497-5p expression changes. D The expression of HMGA2 was examined by immunohistochemical staining of sections from the xenograft model. Scale bar, 25 μm. E Representative bioluminescence images of mice after tail vein injection of stably expressing sh-ZFAS1 or sh-ZFAS1 plus HMGA2 plasmid SW1990 cells. F The expression of HMGA2 were detected by immunohistochemistry of sections from the metastatic lung nodules. Scale bar, 25 μm. *P < 0.05, **P < 0.01, ***P < 0.001.

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