Fig. 1: Correlation between SAP130 and Mincle expression in mouse model of acute kidney injury. | Cell Death & Disease

Fig. 1: Correlation between SAP130 and Mincle expression in mouse model of acute kidney injury.

From: SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury

Fig. 1

A Acute kidney injury (AKI) was induced by unilateral ureteral obstruction (UUO) and cisplatin injection in mice. Scale bar, 100 μm. B–C SAP130 expression was increased in AKI mice compared to controls as detected by RT-PCR. D Immunofluorescence staining showed increased cytoplasmic SAP130 expression which is evident in tubules of the injured kidney, accompanying with upregulated expression of Mincle. Scale bar, 50 μm. E Confocal microscopy showed that CD68+ macrophages (green) were surrounded to the area of tubules with strong SAP130 expression (red). Scale bar, 50 μm. F–I Quantitative analysis of SAP130 and Mincle positive cells. Data were presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 compared to Ctrl. Ctrl Control, Cis cisplatin.

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