Fig. 4: The effects of MTDH on protein expressions of Gem-treated breast cancer cells. | Cell Death & Disease

Fig. 4: The effects of MTDH on protein expressions of Gem-treated breast cancer cells.

From: MiR-9-3p regulates the biological functions and drug resistance of gemcitabine-treated breast cancer cells and affects tumor growth through targeting MTDH

Fig. 4

A The effects of silenced MTDH on expressions of p53, VEGF, MMP-2, and MMP-9 in MCF7 cells were detected by Western blot (n = 3, *P < 0.05, **P < 0.01, vs. siNC; ##P < 0.01, vs. siNC + Gem; ^^P < 0.01, vs. siMTDH). B The effects of overexpressed MTDH on expressions of p53, VEGF, MMP-2, and MMP-9 in HCC1806 cells were detected by Western blot (n = 3, ++P < 0.01, vs. NC; ▲▲P < 0.01, vs. NC + Gem; △△P < 0.01, vs. MTDH). C The effects of silenced MTDH on expressions of E-Cadherin, N-Cadherin, and Vimentin in MCF7 cells were detected by Western blot (n = 3, *P < 0.05, **P < 0.01, vs. siNC; ##P < 0.01, vs. siNC + Gem; ^^P < 0.01, vs. siMTDH). D The effects of overexpressed MTDH on expressions of E-Cadherin, N-Cadherin, and Vimentin in HCC1806 cells were detected by Western blot (n = 3, +P < 0.05, ++P < 0.01, vs. NC; ▲P < 0.05, ▲▲P < 0.01, vs. NC + Gem; △△P < 0.01, vs. MTDH). VEGF vascular endothelial growth factor, MTDH Metadherin, NC negative control.

Back to article page