Fig. 2: Kallikrein-related peptidase 8 (KLK8) gene is highly expressed in colorectal cancer and correlates with poor prognosis. | Cell Death & Disease

Fig. 2: Kallikrein-related peptidase 8 (KLK8) gene is highly expressed in colorectal cancer and correlates with poor prognosis.

From: KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1

Fig. 2

A KLK8 expression in colorectal cancer tissues at different stages, from I to IV based on AJCC Cancer Staging Manual, were measured using IHC. KLK8 expression scores were shown in (B). C KLK8 expression in normal colon tissue, adenoma and metastatic adenocarcinoma was measured using IHC. KLK8 expression scores were shown in (D). E Comparison of the percent of survival of patients with high-level KLK8 (KLK8-High) and low level KLK8 (KLK8-Low) expression using the Kaplan−Meier method (n = 350). P < 0.0001. **P < 0.01 versus normal colon.

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