Fig. 7: PAR1 inhibition suppresses the migration and invasion of colorectal cancer cells induced by KLK8 in vitro.

A, B Wound-healing assay was conducted to assay the migration of CRC cells. C−F Transwell assays showing migration/invasion of cells. Cells invading through uncoated inserts and Matrigel-coated inserts were stained, ×400. All of the data are presented as the mean ± SEM from three independent experiments. **P < 0.01 vs. Lv-control; ##P < 0.01 vs. Lv-KLK8.