Fig. 9: PAR1 inhibition suppresses proliferation and metastasis in colorectal cancer cells induced by KLK8 in vivo. | Cell Death & Disease

Fig. 9: PAR1 inhibition suppresses proliferation and metastasis in colorectal cancer cells induced by KLK8 in vivo.

From: KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1

Fig. 9

A Photographs of tumours excised from mice injected with normal cells or cells with modified KLK8 expression (n = 6 per group). After 28 days, the mice were sacrificed, and the tumours were weighed (B). C KLK8-overexpressing cells produced larger tumour masses than control cells. D Representative images of livers after injection of modified RKO cells into the spleen. The metastatic nodules in the Lv-KLK8 group is clearly shown. E Representative images of PET CT and H&E staining (F) of metastatic nodules in the livers, ×100. G The numbers of metastatic nodules in the livers. H Immunohistochemical staining for E-cadherin, N-cadherin, vimentin and occludin expression in harvested mouse tumour samples, ×200. The statistical analyses are shown (n = 6). *P < 0.05, **P < 0.01 vs. Lv-control; #P < 0.05, ##P < 0.01 vs. Lv-KLK8.

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