Fig. 1: Expression and secretion of SRGN are upregulated in GCTB.
From: Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone
A Hematoxylin and eosin (H&E) staining of GCTB and osteosarcoma (OS) tissues. Arrows point to osteoclast-like MGCs in GCTB. B Genomic sequencing of H3.3 mutations in GCTB primary cell lines (GCTB-1, GCTB-2, GCTB-3 and GCTB-19) and OS cell lines (U2OS and MG63). C Heatmap of mass-spectrum secretomic analysis of GCTB and OS cells. D, E SRGN secretion (D) and mRNA levels (E) in GCTB and OS cells. F SRGN expression in various bone tumor cell lines in the Cancer Cell Line Encyclopedia database. G Serological SRGN levels of GCTB patients and healthy people. Scale bar, 100 μm. P values were obtained by two-tailed unpaired t test (F, G). Box plots display values of minimum, first quartile, median, third quartile, and maximum. Bar graphs are shown as mean ± s.d.
