Fig. 4: TNFSF10-neutralizing antibody treatment preserved retinal structure in 15-month-old 3xTg-AD mice. | Cell Death & Disease

Fig. 4: TNFSF10-neutralizing antibody treatment preserved retinal structure in 15-month-old 3xTg-AD mice.

From: Targeting the miRNA-155/TNFSF10 network restrains inflammatory response in the retina in a mouse model of Alzheimer’s disease

Fig. 4

Hematoxylin and eosin staining of retinal tissue of WT and 3xTg-AD mice were performed to analyze retina morphological changes following chronic treatment with vehicle or TNFSF10-neutralizing antibody. Original magnification, x200. Scale bar = 200 µm. N = 5 animals; 5 independent retinal samples per group. NFL nerve fiber layer, GCL ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL outer nuclear layer, IS inner segment; OS outer segment, RPE retinal pigment epithelial.

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