Table 1 miRNAs-TNFSF10 signaling pathways interactions in retina of 3xTg-AD mice.

From: Targeting the miRNA-155/TNFSF10 network restrains inflammatory response in the retina in a mouse model of Alzheimer’s disease

 

3-month-old 3xTg-AD mice

9-months-old 3xTg-AD mice

15-month-old 3xTg-AD mice

miR-155-5p

TNFRSF10B

TNFRSF10A

↑* miRNA fold regulation

↓ predicted target regulation

↑* miRNA fold regulation

↓ predicted target regulation

↑* miRNA fold regulation

↓ predicted target regulation

miR-126-3p

TNFRSF10B

↑* miRNA fold regulation

↓ predicted target regulation

↑* miRNA fold regulation

↓ predicted target regulation

↓ miRNA fold regulation

↑ predicted target regulation

miR-23a-3p

TNFRSF10B

↑* miRNA fold regulation

↓ predicted target regulation

↑ * miRNA fold regulation

↓ predicted target regulation

↓* miRNA fold regulation

↑ predicted target regulation

miR-34a-5p

TNFRSF10D

↑* miRNA fold regulation

↓ predicted target regulation

↑ miRNA fold regulation

↓ predicted target regulation

↓ miRNA fold regulation

↑ predicted target regulation

miR-27a-3p

FADD

↑* miRNA fold regulation

↓ predicted target regulation

↑* miRNA fold regulation

↓ predicted target regulation

↓* miRNA fold regulation

↑ predicted target regulation

  1. Note: * p < 0.05 vs. WT age-matched mice. Bold characters highlight that most of dysregulated miRNAs in the retina of 15-month-old 3xTg-AD mice, are down-regulated, leading to putative up-regulation of experimentally validated targets of TNFSF10 pathway. In humans, TNFRSF10A is a target of miR-155.
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