Fig. 4: Ass1 knockout in the intestinal epithelium does not affect regeneration after damage by irradiation.
From: Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis
A Schematic overview of the mouse model. B qRT-PCR for Ass1 in small intestinal lysates of Ass1wt/wt and Ass1−/− mice 96 h after irradiation. Actb was used as a reference gene. ***p < 0.001 by Student’s t-test. C Immunohistochemistry for ASS1 in small intestinal tissue of Ass1wt/wt and Ass1−/− mice 96 h after irradiation. Representative images shown. Scale bar indicates 100 µm. D Average villus length. E Amount of hyperproliferative crypts per mm intestine. n = 8 mice per group.
