Fig. 5: Ass1 knockout in the intestinal epithelium does not affect tumorigenesis in vivo.
From: Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis
A Schematic overview of the Apcfl/fl mouse model. B Relative weight compared to start tamoxifen injections. C Immunohistochemistry for ASS1 (upper panels) and BrdU (lower panels) of Ass1wt/wt and Ass1−/− mice 5 days after recombination. Representative images are shown. Scale bar represents 50 µm. D Amount of BrdU-positive cells per crypt in the small intestine. E Amount of cleaved caspase-3-positive cells per crypt in the small intestine. F Schematic overview of the Apcwt/fl mouse model. G Relative weight compared to start tamoxifen injections. H Immunohistochemistry for ASS1 in adenomas in Ass1wt/wt and Ass1−/− mice. Scale bar represents 100 µm. I Amount of adenomas in both groups. J Average adenoma size.
