Fig. 4: Satb2 is required for the differentiation of DA neurons in DM and for the maintenance of DA neurons in VL.
From: Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1
a–c’ Comparison of TH expression in the ARC of control and Satb2 CKO mice at different embryonic stages. TH mRNA is detected in the VL (arrows) in both control (a–c) and Satb2 CKO (a’–c’) embryos with no obvious differences at E14.5, E15.5, or E16.5. TH mRNA is present in the DM (triangles) of control mice at E15.5 (b) and E16.5 (c) whereas no TH transcripts are found in age-matched Satb2 CKO mice (b’, c’). d, d’ Reduction of TH expression is first detected in the VL (arrow) of Satb2 CKO mice at P14, when few TH+ neurons are present in the DM (triangle) relative to controls. 3V third ventricle. Scare bars = 100 μm in a–d’.
