Fig. 1: MPT0B291 reverses abnormal clinical features of DDR genes in GBM. | Cell Death & Disease

Fig. 1: MPT0B291 reverses abnormal clinical features of DDR genes in GBM.

From: Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells

Fig. 1

A Heatmap representation of the expression levels of 177 well-defined DDR genes in 137 clinical primary or recurrent GBM samples from the TCGA database. Twenty-five upregulated genes (the clustered DDR genes) compared to solid normal controls were clustered using the Euclidean distance method and shown in the dashed frame on the right panel. B Heatmap representation of fold changes of the clustered DDR genes identified by the above analysis in primary and recurrent tumors versus normal brain tissue and in MPT0B291-treated U87MG-R and P3-R cells versus DMSO-treated parental cells. C Venn diagram showing overlaps between the number of DDR genes that were upregulated (two-fold increase) in TCGA-GBM dataset or downregulated (1.5-fold decrease) after MPT0B291 treatment in U87MG-R and P3-R cells. D MetaCore analysis was conducted on the intersected genes between TCGA-GBM dataset and MPT0B291-treated U87MG-R/P3-R cells according to the above analysis to evaluate their functions. The yellow and blue bars show results of 14 and 5 co-regulated DDR genes, respectively. The number of involved genes is shown on the bars.

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