Fig. 1: Effects of metformin treatment on biochemical index and renal pathological changes in the kidney of HFD/STZ induced diabetic mice. | Cell Death & Disease

Fig. 1: Effects of metformin treatment on biochemical index and renal pathological changes in the kidney of HFD/STZ induced diabetic mice.

From: AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice

Fig. 1

A–C Serum Cr, BUN and blood glucose levels of three groups mice at 24 weeks after STZ injection. D Body weight of three groups mice at 24 weeks after STZ injection. E The kidney weight/body weight of three groups mice at 24 weeks after STZ injection. F Twenty-four hours proteinuria content of three groups mice at 24 weeks. Values are presented as the mean ± SD, *P < 0.05 vs. control group, #P < 0.05 vs. STZ + HFD group, n = 8. G Renal tissue sections stained with H&E (a–c) and PAS (d–f) (magnification ×400). Electron microscopy (EM) analysis showed that significant ultrastructural changes in diabetic mice including the fusion of the foot processes and the thickening of the glomerular basement membrane. While these injuries were obviously alleviated by metformin treatment. (g–i magnification ×10,000), n = 3. H Glomerular damage scores. I Tubulo-interstitial damage scores, *P < 0.05 vs. control group, #P < 0.05 vs. STZ + HFD group, n = 3.

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