Fig. 4: Characterization of the p53-regulated genes in HSPCs under homeostatic conditions. | Cell Death & Disease

Fig. 4: Characterization of the p53-regulated genes in HSPCs under homeostatic conditions.

From: p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress

Fig. 4

A–C Normalized counts per million (CPM) expression of Eda2r, Gfi1, and Ndn genes from the RNA-Seq of murine WT and p53KO HSPCs with and without whole-body irradiation. D–F Genomic snapshots of Eda2r, Gfi1, and Ndn genes. ChIP-Seq tracks of p53 in untreated (UT) and irradiated (IR) hematopoietic progenitor cells Ba/F3 and HPC7, and input DNA from the same cells are shown in the top five lanes. The gene feature track is shown in the middle. RNA-Seq tracks of the summation of gene expression in each group are shown in the bottom four lanes. The maximum data range of each track is indicated at the top-right corner of the track.

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