Fig. 4: Cardiomyocyte-specific overexpression of GALNT4 attenuates the cardiac hypertrophy induced by TAC surgery.
From: Role of GALNT4 in protecting against cardiac hypertrophy through ASK1 signaling pathway
A The levels of GALNT4 in AAV9–GALNT4, AAV9-Vector mice were analyzed by western blotting. B–D The ratio of HW/ BW, LW/BW, and HW/TL in the AAV9-GALNT4 group and sham group (n = 10 mice per group). E–H LVEDd, LVESd, EF%, and FS% were analyzed in each group (n = 10 mice per group). I H&E staining images (n = 6 mice per group) and heart CSA (n = 120 cells in each group) in AAV9–GALNT4 and control mice. J Images of PSR staining (left, n = 6 mice per group) and percentage of LV collagen volume in the indicated group. L, M The levels of markers of hypertrophy and fibrosis were analyzed by qPCR (n = 4 mice per group). *p < 0.05 vs. AAV9-Vector sham, **p < 0.01 vs. AAV9-Vector sham, #p < 0.05 vs. AAV9-Vector TAC, ##p < 0.01 vs. AAV9-Vector TAC.
