Fig. 7: The level of SNHG17 is positively correlated with that of LRPPRC and c-Myc in human HCC tissues. | Cell Death & Disease

Fig. 7: The level of SNHG17 is positively correlated with that of LRPPRC and c-Myc in human HCC tissues.

From: LncRNA SNHG17 interacts with LRPPRC to stabilize c-Myc protein and promote G1/S transition and cell proliferation

Fig. 7

A Expression of SNHG17, LRPPRC, and c-Myc protein in paired HCC (T) and adjacent non-tumor livers (N). The protein level of LRPPRC or c-Myc was assessed by Western blotting. The intensity of each band was quantified. The band intensity of LRPPRC and c-Myc in each sample was normalized to that of GAPDH (internal control). The values under each pair of samples indicate the fold change of the normalized levels of the indicated molecules in HCC, relative to that in the matched non-tumor livers. The normalized RNA levels of SNHG17 were derived from Fig. 1F. B The protein levels of LRPPRC and c-Myc increased in HCC tissues. Quantified protein levels in paired HCC (T) and adjacent non-tumor livers (N) from Fig. 7A were compared. C Positive correlation among the expression levels of SNHG17, LRPPRC, and c-Myc in human HCC tissues. D Working model of the SNHG17/LRPPRC/c-Myc regulatory axis. P values were assessed by paired Student’s t test (B), or Pearson’s correlation coefficient (C). *, P < 0.05; ***, P < 0.001.

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