Fig. 2: The EV-mediated communication between PDAC and cancer stem cell/cancer-initiating cell (CSC/CIC). | Cell Death & Disease

Fig. 2: The EV-mediated communication between PDAC and cancer stem cell/cancer-initiating cell (CSC/CIC).

From: Extracellular vesicles in pancreatic cancer progression and therapies

Fig. 2

PDAC cell-derived EVs contain cargos such as CD44v6, C1P, Tspan8 and CD151, while CSC/CIC-derived EVs carry factors including Tspan8, CD151, miR210 and miR-195-5p that regulate biological functions in the counterparts. This includes upregulation of stemness and survival genes in the recipient cells that provide resistance to radiation and chemotherapies, stimulate protein secretion for stromal reprogramming and angiogenesis, and the switching to metastatic phenotype for metastasizing to distant sites.

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