Fig. 2: Scheme of the effects observed after KNL1, ASPM, CENPE, CITK, and KIF14 loss.
From: Inhibiting microcephaly genes as alternative to microtubule targeting agents to treat brain tumors
The loss of KNL1 and CENPE expression in proliferating cells leads to misaligned chromosomes and altered microtubule-kinetochore attachment. CENPE, ASPM, and CITK loss determines altered spindle poles orientation and oblique divisions. ASPM, CITK, and KIF14 loss leads to cytokinesis failure with the formation of multinucleated cells. These alterations can result in mitotic catastrophe or apoptosis or cell cycle arrest.
