Fig. 3: A continuous change of specific gene signature in ERlow luminal cells was correlated with the tumor progression and clinical outcome. | Cell Death & Disease

Fig. 3: A continuous change of specific gene signature in ERlow luminal cells was correlated with the tumor progression and clinical outcome.

From: Single-cell transcriptomics reveal the heterogeneity and dynamic of cancer stem-like cells during breast tumor progression

Fig. 3

a Pseudo-time trajectory analysis of the six sub-clusters of luminal epithelial cells annotated by clusters (left) and tumor progression stages (right). b Pseudo-time trajectory of cells in each luminal epithelial cell cluster. c The heatmap showed the sample composition of each cluster, indicating that the composition of week 17 was gradually increased along cluster LuE1, LuE5, LuE2, LuE4, LuE3, and LuE6. d Heatmap of expression profile of signature genes in indicated modules identified by WGCNA (Weighted Gene Co-expression Network Analysis). A summary list of genes associated with corresponding WGCNA module were shown in supplementary Table 3. e The Kaplan–Meier relapse free survival curves of patients were grouped by the gene signatures in WGCNA modules. The left corresponded to the module 1 and the right corresponded to the module 2. f Boxplot depicted the distribution of malignant score derived from luminal B patient samples in TCGA. Mann-Kendall trend test was performed using the median value of each stage by “trend” package in R.

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