Fig. 3: Ela activates AMPK in the liver and adipose tissues.
From: Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK
A Wild-type C57BL/6 mice were intraperitoneally injected with DMSO, 5 mg/kg Ela or 10 mg/kg Ela. Blood glucose level was monitored at 0 h, 0.5 h, 1 h, 4 h, 6 h, and 20 h after injection n = 5. B Wild-type C57BL/6 mice were intraperitoneally injected with DMSO or Ela (80 mg/kg). Mice livers, EWAT, and muscles were harvested 0.5 h and 1 h after injection. WB analysis was performed with the indicated antibodies. C Wild-type C57BL/6 mice were intraperitoneally injected with DMSO or Ela (40 mg/kg). Mice livers and muscles were harvested 4 h and 8 h after injection. WB analysis was performed with the indicated antibodies. D Wild-type C57BL/6 mice were intraperitoneally injected with DMSO or Ela (80 mg/kg). Adipose tissues from different fat-pad depots were harvested 1 h and 4 h after injection. WB analysis was performed with the indicated antibodies. Data are expressed as mean ± SEM. **P < 0.01, ***P < 0.001 for the indicated comparisons by two-way ANOVA.
