Fig. 8: Schematic representation of the role of NPRA on the angiogenesis in GC.
From: Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process
In summary, NPRA promoted GC angiogenesis by activating the HIF-1α–VEGF axis. NPRA interacted with HIF-1α protein and stabilized it to prevent its ubiquitination degradation.
