Fig. 6: KLF7 is a direct target of miR-370-5p. | Cell Death & Disease

Fig. 6: KLF7 is a direct target of miR-370-5p.

From: Circular RNA circUBE2J2 acts as the sponge of microRNA-370-5P to suppress hepatocellular carcinoma progression

Fig. 6

A Venn diagram analyses of three independent databases reveals 72 possible targets of miR370-5P. B Pearson’s correlation analysis showed that miR-370-5P was inversely correlated with KLF7 mRNA levels. C Overexpression and downregulation of miR-370-5P in MHCC97H,HLF and HepG2 cells changes the KLF7 mRNA level as measured by qRT-PCR. D Bioinformatics predicted binding sites of miR-370-5P within KLF7 were shown. E A schematic drawing showing the putative binding sites. The mutant version of KLF7 is presented. F, G Relative luciferase activity determined 48 h after transfecting HEK293T cells (D) and HLF cells (E) with miR-370-5P mimic/NC or KLF7 WT/Mut. Data are presented as means ± SD, n = 3. **p < 0.05; **p < 0.01. WT wild-type, Mut mutant-type, m miR370-5P mimcs, mn mimcs nc, i miR370-5P inhibitor, in inhibitor nc.

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