Fig. 2: CGI-58 deficiency induces lipid accumulation, oxidative stress, and inflammation in the hearts of ND and HFD-fed mice. | Cell Death & Disease

Fig. 2: CGI-58 deficiency induces lipid accumulation, oxidative stress, and inflammation in the hearts of ND and HFD-fed mice.

From: Cardiac-specific CGI-58 deficiency activates the ER stress pathway to promote heart failure in mice

Fig. 2

CGI-58fl/fl and CGI-58cko mice were fed with ND and HFD for 3 months. A Oil Red O staining of the heart to measure lipid accumulation (n = 5). B DHE staining of the heart sections (left) and the quantification of ROS level (right, n = 5). Scale bar 50 μm. C qPCR analyses of IL-1β and IL-6 mRNA expression (n = 5). D, E Measurement of TG and TC content in the heart (n = 5). F, G qPCR analyses of ATGL, PPARα, CPT-1m, HMGCS2, and LCAD mRNA levels (n = 5). Data are presented as mean ± SEM, and n represents the number of animals per group. *P < 0.05, **P < 0.01, ***P < 0.001.

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