Fig. 4: Proteomic exploration of the biological processes of CGI-58cko heart.
From: Cardiac-specific CGI-58 deficiency activates the ER stress pathway to promote heart failure in mice
A–D GO and KEGG pathway analysis of the biological processes in the hearts from CGI-58fl/fl and CGI-58cko mice. The pathways involved in ER stress, phagosome, lysosome, and fatty acid metabolism are significantly enriched in CGI-58cko hearts. The horizontal axis represents −log10 (Fisher’ exact value); the ordinate represents the GO or KEGG pathway. E The heatmap illustrates the expression level changes of the statistically significant proteins involved in ER stress, phagosome, lysosome, and fatty acid metabolism between the CGI-58fl/fl and CGI-58cko mice.
