Fig. 8: UCSC genome browser ChIP-seq analysis of the 6 upregulated promoters in COVID-19 cancer patients. | Cell Death & Disease

Fig. 8: UCSC genome browser ChIP-seq analysis of the 6 upregulated promoters in COVID-19 cancer patients.

From: Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients

Fig. 8

Analysis on IFI6, IFIT1, IFIT3, MX1, SLC1A5, TNFRSF17 promoters using UCSC genome browser and selecting available cells of blood origin (GM12878 and K562 cell line). The analysis has been performed on a region spanning 10Kb upstream TSS (highlighted in light blue) and the first intron of the gene. The binding for the following transcriptional factors have been searched: BATF, E2F family, P300, GATA family, HDAC family, IRF family, RUNX family, STAT family, TEAD4, RB1. NFY, and SP1 ubiquitous factors were used as control. The H3K4me1, HeK4me3, and H3K27ac have been used to identify the euchromatin region around the start sites. The same analysis for the downregulated genes is shown in Supplementary Fig. S7.

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