Fig. 2: Cytosolic p62 is associated with advanced HNSCC.
From: p62/SQSTM1-induced caspase-8 aggresomes are essential for ionizing radiation-mediated apoptosis
a Immunohistochemical analysis of p62 in normal tissue (top), low grade (middle), and high grade (bottom) HNSCC. Scale bar, 50 μm. b Immunohistochemical analysis of cytosolic and nuclear p62 localization corresponding to tumor progression. Scale bar, 50 μm. c Frequency of nuclear p62 in normal tissues and low, moderate, and high-grade HNSCC as assessed by expression levels (score 0–3), analyzed by Chi-square test, p = 0.025. d Frequency of cytoplasmic p62 in normal tissues and low, moderate, and high-grade HNSCC as assessed by expression levels (score 0–3), analyzed by Chi-square test, p < 0.001. e Frequency of overall p62 in normal tissues and low, moderate, and high-grade HNSCC as assessed by expression levels in both nucleus and cytoplasm (score 0–3), analyzed by Chi-square test, p = 0.001.
