Fig. 1: II/R-induced ALI promotes ferroptosis.
From: Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11
A Endogenous Fe levels in the lungs of IIR-ALI mice, as evidenced by Fe assay. B Representative transmission electron micrographs of lung ultrastructure. Scale bars: 500 nm. C, D Evaluation and quantification of the GPX4, ferritin, and ferroportin protein expressions, under all conditions. E Evaluation of the lipid peroxide MDA levels under all conditions. F GSH levels under all conditions. G HE staining of the murine lung tissues after IIR and IIR + Fer-1. Scale bars: 200 μm. H The lung pathological damage score illustrating addition and decrease after Fer-1 administration, respectively. Data are expressed as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001. Error bars denote standard error from three individual experiments.
