Fig. 2: The Nrf2/TERT/SLC7A11 axis is activated during II/R and the ferroptotic process is dysregulated in the Nrf2−/− mice after II/R.
From: Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11
A Evaluation of Nrf2 and its potential downstream targets in the murine lung tissues, under different conditions, as evidenced by western blotting. B Quantification of the examined proteins. C mRNA levels of the examined factors. D Representative transmission electron micrographs of the lung tissue ultrastructures. Scale bar: 500 nm. E HE staining of lung sections, observed under a light microscope. Scale bar: 200 μm. F Pathological scores, as determined by an experienced pathologist. G MDA levels under different conditions. H GSH levels under different conditions. I Evaluation of essential proteins involved in ferroptosis regulation within lung tissues, under different conditions. J Quantification of the examined proteins. K mRNA levels of the examined factors. Error bars denote standard error from three individual experiments. Data are expressed as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001. # relative to the IIR-WT mice.
