Fig. 4: p32 knockdown in mouse melanoma cells impairs their tumor-forming capacity and modulates tumor microenvironment in vivo. | Cell Death & Disease

Fig. 4: p32 knockdown in mouse melanoma cells impairs their tumor-forming capacity and modulates tumor microenvironment in vivo.

From: p32 promotes melanoma progression and metastasis by targeting EMT markers, Akt/PKB pathway, and tumor microenvironment

Fig. 4

A Representative images showing subcutaneous tumors size and weight and B representative H&E images of tumor section in C57BL/6 mice injected with control and transfected B16F10 cells subcutaneously. C Immunohistochemical analysis of E-cadherin, vimentin, proliferation (Ki-67), angiogenesis (CD34), leukocyte (CD45), and macrophage (F4/80) infiltration in subcutaneous tumors and bottom panel bar graphs represent their quantification. All the data are represented as mean ± SD. Student’s t-test was used for all statistical analyses, n = 5 (**P < 0.01, *P < 0.05).

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