Fig. 5: p32 knockdown impairs mice melanoma cells lung metastasis and modulate associated tumor microenvironment in vivo. | Cell Death & Disease

Fig. 5: p32 knockdown impairs mice melanoma cells lung metastasis and modulate associated tumor microenvironment in vivo.

From: p32 promotes melanoma progression and metastasis by targeting EMT markers, Akt/PKB pathway, and tumor microenvironment

Fig. 5

A Representative images showing tumors in lung after intravenous injection of control and transfected B16F10 cells. B Representative H&E images of lung tissue sections showing tumors in C57BL/6 mice injected with control and transfected B16F10 cells intravenously. C Immunohistochemical analysis of proliferation (Ki-67), angiogenesis (CD34), leukocyte (CD45), and macrophage (F4/80) infiltration in intravenous tumors from C57BL/6 mice after injecting control and shRNA-transfected B16F10 cells and right panel bar graphs represent their quantification. All the data are represented as mean ± SD. Student’s t-test was used for all statistical analyses, n = 5 (***P < 0.001, **P < 0.01).

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