Fig. 2: CHL1 promotes the proliferation and suppresses apoptosis of NSCLC cells by activating MAPK signaling pathway. | Cell Death & Disease

Fig. 2: CHL1 promotes the proliferation and suppresses apoptosis of NSCLC cells by activating MAPK signaling pathway.

From: Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway

Fig. 2

A The expression level of CHL1 mRNA in BEAS-2B, A549, and SK-MES-1 cells. B The expression level of CHL1 protein in BEAS-2B, A549, and SK-MES-1 cells. C The expression level of CHL1 mRNA in A549 and SK-MES-1 cells with the treatment of shRNA-NC and shRNA-CHL1. D The expression level of CHL1 protein in A549 and SK-MES-1 cells with the treatment of shRNA-NC and shRNA-CHL1. E The expression level of CHL1 mRNA in A549 and SK-MES-1 cells with the treatment of OE-NC and OE-CHL1. F The expression level of CHL1 protein in A549 and SK-MES-1 cells with the treatment of OE-NC and OE-CHL1. G MTS assay for the growth of A549 cells with the treatment of shRNA-NC and shRNA-CHL1 at 0, 24, 48, and 72 h. H MTS assay for the growth of SK-MES-1 cells with the treatment of shRNA-NC and shRNA-CHL1 at 0, 24, 48, and 72 h. I MTS assay for the growth of A549 cells with the treatment of OE-NC and OE-CHL1 at 0, 24, 48, and 72 h. J MTS assay for the growth of SK-MES-1 cells with the treatment of OE-NC and OE-CHL1 at 0, 24, 48, and 72 h. K Apoptotic assay for A549 cells with the treatment of shRNA-NC and shRNA-CHL1. L Apoptotic assay for SK-MES-1 cells with the treatment of shRNA-NC and shRNA-CHL1. M Apoptotic assay for A549 cells with the treatment of OE-NC and OE-CHL1. N Apoptotic assay for SK-MES-1 cells with the treatment of OE-NC and OE-CHL1. O The expression levels of the MAPK signaling pathway downstream molecules with the treatment of shRNA-NC and shRNA-CHL1. P The expression levels of the MAPK signaling pathway downstream molecules with the treatment of OE-NC and OE-CHL1. **P < 0.01, ***P < 0.001.

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