Fig. 2: Nrmt1−/− mice show degeneration of hippocampal neurons. | Cell Death & Disease

Fig. 2: Nrmt1−/− mice show degeneration of hippocampal neurons.

From: Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development

Fig. 2

Cresyl violet staining of hippocampal neurons shows similar morphology between Nrmt1−/− and WT mice at a P14 and b 6 weeks. However, at c 3 months, Nrmt1−/− mice show degeneration of neurons in the CA3 (arrow) and DG (arrowhead). d By 6 months, neuronal staining is almost completely absent in the CA3 and DG. Quantification of e CA3 and f DG volume. *p < 0.05 and **p < 0.005 as determined by unpaired t-test, n = 3. Error bars represent mean ± SEM. Scale bar = 400 μm.

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