Fig. 5: An early expansion of the RGL pool in the SVZ of Nrmt1−/− mice is followed by premature depletion. | Cell Death & Disease

Fig. 5: An early expansion of the RGL pool in the SVZ of Nrmt1−/− mice is followed by premature depletion.

From: Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development

Fig. 5

a, c At P0, there is a significant increase in GFAP staining in the SVZ (brackets) of Nrmt1−/− mice. b, c At 3 months, GFAP staining is significantly decreased in the SVZ (arrows) of Nrmt1−/− mice, indicating the early expanded GFAP+ pool has become depleted. d, e Although the width of the SVZ and intensity of GFAP staining are significantly higher in Nrmt1−/− mice at P0, the ratio of Ki-67/GFAP is lower than WT, indicating the GFAP+ cells are not undergoing higher rates of proliferation in Nrmt1−/− mice. **p < 0.005, ***p < 0.0005, and ****p < 0.0001 as determined by unpaired t-test, n = 3–4. Error bars represent mean ± SEM. Scale bar = 1000 μm.

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