Fig. 6: Neurons in Nrmt1−/− mice remain in the cell cycle and ultimately undergo apoptosis. | Cell Death & Disease

Fig. 6: Neurons in Nrmt1−/− mice remain in the cell cycle and ultimately undergo apoptosis.

From: Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development

Fig. 6

a At P14, Ki-67 staining (red) is restricted to the SVZ (arrow) in WT mice. In Nrmt1−/− mice, Ki-67+ cells are also found in the neighboring striatum and significantly more of these Ki-67+ cells co-stain (yellow) with NeuN (green), a marker of mature neurons. Over 10% of NeuN-positive cells co-stain with Ki-67. b Punctate cleaved caspase-3 staining (green) appears in Nrmt1−/− mice by 6 weeks and this coincides with the loss of NeuN (gray) and Ki-67 (red) double-positive neurons (pink) in the striatum. ****p < 0.0001 as determined by unpaired t-test, n = 4. Error bars represent mean ± SEM. Scale bar = 1000 μm.

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