Fig. 2: Ionizing radiation downregulates phosphorylation of ERα. | Cell Death & Disease

Fig. 2: Ionizing radiation downregulates phosphorylation of ERα.

From: Ionizing radiation downregulates estradiol synthesis via endoplasmic reticulum stress and inhibits the proliferation of estrogen receptor-positive breast cancer cells

Fig. 2

MCF7 and T47D cells were irradiated with X-rays at different doses. Twenty-four hours after irradiation, ERα mRNA transcription decreased (A). Ionizing radiation downregulated the expression and phosphorylation of ERα without (B) or with (C) estradiol supplementation. The expression of ERα decreased after 2 Gy of radiation in MCF7 tumor cells (D). Ionizing radiation downregulated the expression of SGK3 without (E) or with (F) estradiol supplementation (mean ± SD of triplicate assessments, Student’s t-test, **p < 0.01, ***p < 0.001).

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