Fig. 1: The chromosomal location, expression characteristics of ARSD gene, and its correlation with clinicopathological features in BC. | Cell Death & Disease

Fig. 1: The chromosomal location, expression characteristics of ARSD gene, and its correlation with clinicopathological features in BC.

From: ARSD, a novel ERα downstream target gene, inhibits proliferation and migration of breast cancer cells via activating Hippo/YAP pathway

Fig. 1

A A cluster of sulfatase Genes on Xp22.3. B Tissue expression for human ARSD gene. RNA expression distribution of ARSD in 55 tissue types and 6 blood cell types, created by combining the data from three transcriptomics datasets (HPA, GTEx, and FANTOM5) using internal normalization pipeline. C ARSD protein expression in breast tissue according to Human immunochemistry data on 83 different normal cell types from 44 tissue types from the Human Protein Atlas project. D Comparison of ARSD under-expression across 11 analyses. E In Rechardson Breast2 analysis, ARSD presents the lower expression level in breast tumor samples in comparison of normal breast tissues (https://www.oncomine.org/). F ARSD presents the lower expression level in breast tumor samples in comparison of normal breast tissues. G ARSD presents the lowest expression level in basal-like breast cancer either in Hu’s subtype or in PAM50 subtype. Compared with ER- breast cancers, ARSD presents the higher expression level in ER+ breast cancers. ARSD expression gradually decreases according to the NPI grade. H Boxplots created by Kaplan–Meier analysis (https://kmplot.com/analysis/) show the overall survival (OS), relapse-free survival (RFS), distant metastases-free survival (DMFS), and post-progression survival (PPS) of breast cancer patients according to ARSD expression.

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