Fig. 4: USP5 knockdown inhibits tumor growth in Lewis lung cancer xenografts.
From: USP5 facilitates non-small cell lung cancer progression through stabilization of PD-L1
A Western blotting analysis of Lewis lung carcinoma (LLC) cells expressing control (ctrl) or USP5 shRNA. B, C LLC cells expressing ctrl or USP5 shRNA have been implanted into C57/BL6 mice, B Tumor growth curve and C tumor weights have been measured. D Immunohistochemistry (IHC) analysis of USP5, PD-L1, and Ki67 levels in LLC xenografts expressing ctrl or USP5 shRNA. Representative image (left) and quantification (right) of IHC stainig were shown. E IHC staining analysis of CD8 and Grazyme B positive cells in LLC xenografts expressing ctrl or USP5 shRNA. Data represents the mean ± SD, n = 5 per group. *P < 0.05, **P < 0.01, and ***P < 0.001.
