Fig. 2: Decreased expression of DTYMK inhibited proliferation and increased sensitivity to oxaliplatin in HCC cells. | Cell Death & Disease

Fig. 2: Decreased expression of DTYMK inhibited proliferation and increased sensitivity to oxaliplatin in HCC cells.

From: Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin

Fig. 2

A DTYMK catalyzed the phosphorylation of dTMP to form dTDP. B and C Decreased DTYMK significantly inhibited the proliferation of Huh7 and Hep3B cells, while the supplement of dTDP partly rescued the proliferation ability. D and E Decreased expression of DTYMK could lead to cell cycle arrest and reduce the proportion of cells entering the G1 phase. F Decreased expression of CDK2, CDK4, Cyclin A2, and Cyclin D1 after DTYMK knockdown. G and H Increased sensitivity to oxaliplatin after DTYMK knockdown. I Reduced Bcl-2 and increased cleaved-PARP and Bax in the sh-DTYMK group than in the other groups. DTY, DTYMK; OXA, Oxaliplatin. *p < 0.05; **p < 0.01; ***p < 0.001.

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