Table 1 Univariate and multivariate Cox regression analyses.

From: Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin

Variable

Univariate analysis

Multivariate analysis

 

HR (95% CI)

p value

HR (95% CI)

p value

Gender

 

0.977

  

 Male

1.014 (0.399, 2.578)

   

 Female

Reference

   

Age

 

0.249

  

 <50

Reference

   

 ≥50

0.701 (0.382, 1.287)

   

HBsAg positive

 

0.645

  

 Yes

1.305 (0.403, 4.222)

   

 No

Reference

   

Size (major axis)

 

0.009

 

0.068

 <5 cm

Reference

 

Reference

 

 ≥5 cm

2.432 (1.193, 4.955)

 

2.011 (0.950, 4.259)

 

Intact capsule

 

0.560

  

 Yes

1.199 (0.654, 2.199)

   

 No

Reference

   

AFP > 400

 

0.607

  

 Yes

1.172 (0.642, 2.141)

   

 No

Reference

   

DTYMK expression

 

0.004

 

0.019

 High

2.470 (1.313, 4.647)

 

2.157 (1.137, 4.093)

 

 Low

Reference

 

Reference

 

Liver cirrhosis

 

0.227

  

 Yes

1.453 (0.788, 2.680)

   

 No

Reference

   

Grade

 

0.135

  

 1

Reference

   

 2

1.200 (0.488, 2.950)

   

 3

2.250 (0.861, 5.879)

   

TNM staging (AJCC 7th)

 

<0.001

 

0.072

 I–II

Reference

 

Reference

 

 III–IV

5.032 (2.715, 9.328)

 

2.322 (0.927, 5.814)

 

Tumor number (>1)

 

<0.001

 

0.092

 Yes

4.241 (2.250, 7.994)

 

2.205 (0.880, 5.525)

 

 No

Reference

 

Reference

 
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