Fig. 7: LOXL2 inhibits prolyl hydroxylase (PHD)-dependent hydroxylation of HIF1α. | Cell Death & Disease

Fig. 7: LOXL2 inhibits prolyl hydroxylase (PHD)-dependent hydroxylation of HIF1α.

From: Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness

Fig. 7

A Western blotting showing amounts of hydroxylated HIF1α (HIF1α-OH) and HIF1α in LOXL2 knockdown and control cells treated with 10 μM MG132 for 6 h under normoxic and hypoxic conditions. B Western blotting showing amounts of HIF1α-OH and HIF1α in LOXL2-overexpressing and vector control cells treated with 10 μM MG132 for 6 h under normoxic and hypoxic conditions. C Western blotting showing HIF1α expression in LOXL2 knockdown and control cells treated with or without 1 mM dimethyloxalylglycine (DMOG) for 24 h under normoxic and hypoxic conditions. D Western blotting showing HIF1α expression in LOXL2-overexpressing and vector control cells treated with or without 1 mM DMOG for 24 h under normoxic and hypoxic conditions.

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