Fig. 6: NGF promotes chondrosarcoma metastasis to lungs in vivo. | Cell Death & Disease

Fig. 6: NGF promotes chondrosarcoma metastasis to lungs in vivo.

From: Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis

Fig. 6

A–C NGF and LOX levels, as well as the migratory ability of JJ012 and JJ012/NGF cells, were examined by western blot and Transwell. D The mice were injected with JJ012 or JJ012/NGF cells. Lung metastasis was monitored by bioluminescence imaging at the indicated time intervals, and then quantified by photon images. E, F After 12 weeks, the mice were humanely sacrificed and the lung tissue was excised, photographed, and quantified. G, H Levels of LOX expression in lung tumors were subjected to IHC analysis. I The positive correlation between NGF and LOX protein expression was observed in mice lung tissue. *p < 0.05 compared with the JJ012 group.

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