Table 1 Domain architectures and biological functions of MORC family.
From: MORC protein family-related signature within human disease and cancer
Domain | Functions | Ref. |
|---|---|---|
GHKL-ATPase domain | DNA damage response | [13] |
Genome compacting | [14] | |
Gene regulation | [15] | |
CW-type zinc finger domain | Methylation recognition e.g. H3K4me3 | [16] |
Nucleic acid binding | [17] | |
Protein–protein interaction | [4] | |
Coiled-coil domain | Regulation of nucleic acid binding | [18] |
Regulation of protein–protein interaction | [19] | |
Molecular recognition | [20] |
