Table 4 MORC family associated diseases.
From: MORC protein family-related signature within human disease and cancer
MORC members | Associated diseases | Cell lines | Disease models or patients | Reference |
|---|---|---|---|---|
MORC1 | Male infertility | – | Men with infertility | [73] |
Major depressive disorder (MDD) | CD34+ cells from human cord blood CD3+ T cells from monkey peripheral blood | Prefrontal cortex of adult rats | ||
MORC2 | CMT | Hela cells, patient-derived fibroblasts, and primary neuronal cultures | CMT2 patients | |
MORC3 | Metabolic bone diseases | – | MORC3+/− mice | [45] |
Virus infection | – | Herpes simplex virus 1; human cytomegalovirus | [78] | |
Dermatomyositis | – | Dermatomyositis patients | [79] | |
Down syndrome | D21 and T21 fibroblasts, D21 and T21 lymphoblastoid cells | Mouse Ts1Cje model of DS | [23] | |
Inflammatory disease | – | Patients with IIMs | [80] | |
MORC4 | Diffuse large B-cell lymphomas | GC- and NGC- DLBCL cell lines | Patients with DLBCL | [49] |
Inflammatory disease | – | Patients with pancreatitis | [81] |
